UBE2E3 and RNF4

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (pull down, two hybrid)

		UBE2E3	RNF4
Description		ubiquitin conjugating enzyme E2 E3	ring finger protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	DNA Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding Androgen Receptor Binding
	Biological Process	Protein Ubiquitination Regulation Of Growth Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Androgen Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Body mass index ( 25673413) Celiac disease ( 22057235 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Lymphocyte counts ( 29403010) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Obesity ( 21552555) QT interval ( 29213071) Red blood cell count ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) White blood cell count ( 27863252)	Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)
Interacting Genes		84 interacting genes: ACVR1 ARID3A ARIH2 ASXL2 ATXN1 BARD1 BRCA1 CADPS2 CBL CHFR CHUK CNOT4 CUL1 CUL3 CUL4A DTX3 DTX3L DZIP3 HERC4 HTT IPO11 ITCH KLHL42 MARCHF5 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFKBIA PJA1 PRKN RANGAP1 RBX1 RC3H2 RCBTB1 RFWD3 RING1 RMND5B RNF11 RNF111 RNF114 RNF115 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF31 RNF4 RNF43 RNF5 RNF8 SAE1 SIAH1 SPOP STUB1 TGFBR1 TRIM2 TRIM27 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM54 TRIM63 TTC3 UBA1 UBC UBOX5 UFM1 WWP2 ZNF746 ZNRF1 ZNRF4	39 interacting genes: AR ATXN1 ESR1 GSC2 H3C14 HMGA1 HNF4A IKBKG PATZ1 PGR SKIL SP1 SRPK2 SUMO1 SUMO2 TBP TCF20 TERF2 TRAIP TRIM28 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UEVLD
Entrez ID		10477	6047
HPRD ID		05000	04167
Ensembl ID		ENSG00000170035	ENSG00000063978
Uniprot IDs		Q969T4 R4GNG6	P78317
PDB IDs			2EA6 2XEU 4PPE
Enriched GO Terms of Interacting Partners?
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