DDIT4 and TXNIP

Number of citations of the paper that reports this interaction (PubMedID 21460850)
30

Data Source:
BioGRID (pull down, affinity chromatography technology, imaging technique)

		DDIT4	TXNIP
Description		DNA damage inducible transcript 4	thioredoxin interacting protein
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GO Annotations	Cellular Component	Intracellular Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol
	Molecular Function	14-3-3 Protein Binding	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Response To Hypoxia Neuron Migration Apoptotic Process Brain Development Negative Regulation Of Peptidyl-threonine Phosphorylation Neuron Differentiation Regulation Of TOR Signaling Negative Regulation Of TOR Signaling Protein-containing Complex Disassembly Negative Regulation Of Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Glycolytic Process Neurotrophin TRK Receptor Signaling Pathway Defense Response To Virus Cellular Response To Dexamethasone Stimulus Reactive Oxygen Species Metabolic Process Positive Regulation Of Neuron Death Negative Regulation Of Intracellular Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell
Pathways		TP53 Regulates Metabolic Genes	The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index ( 31513605) Heschl's gyrus morphology ( 25130324)
Interacting Genes		7 interacting genes: GSK3B HSPA4 HSPB2 LRIF1 LRRK2 PDPK1 TXNIP	18 interacting genes: DDIT4 ECD FHL1 HDAC1 HDAC3 HSPB2 ITCH KPNA2 NLGN3 PRKAA1 PTPN11 SCEL SMURF2 TXN TXNRD1 UBR5 ZBTB16 ZBTB32
Entrez ID		54541	10628
HPRD ID		09662	05964
Ensembl ID		ENSG00000168209	ENSG00000265972
Uniprot IDs		A0A024QZQ6 Q9NX09	Q9H3M7
PDB IDs		3LQ9	4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD
Enriched GO Terms of Interacting Partners?
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