TXNIP and FHL1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TXNIP	FHL1
Description		thioredoxin interacting protein	four and a half LIM domains 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding	Molecular_function Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell	Regulation Of Membrane Depolarization Muscle Organ Development Animal Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection
Drugs
Diseases			X-linked myopathy with postural muscle atrophy (XMPMA) Reducing body myopathy (RBM) Scapuloperoneal myopathy (SPM) Emery-Dreifuss muscular dystrophy
GWAS
Interacting Genes		18 interacting genes: DDIT4 ECD FHL1 HDAC1 HDAC3 HSPB2 ITCH KPNA2 NLGN3 PRKAA1 PTPN11 SCEL SMURF2 TXN TXNRD1 UBR5 ZBTB16 ZBTB32	21 interacting genes: AKAP12 CBX4 CDC25C CHEK2 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP USP15 YWHAE
Entrez ID		10628	2273
HPRD ID		05964	02157
Ensembl ID		ENSG00000265972	ENSG00000022267
Uniprot IDs		Q9H3M7	B7Z9A1 Q13642 Q5JXI2
PDB IDs		4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD	1X63 2CUP 2CUR 2EGQ
Enriched GO Terms of Interacting Partners?
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