PRMT7 and EIF2S1

Number of citations of the paper that reports this interaction (PubMedID 30699057)
1

Data Source:
BioGRID (enzymatic study)

		PRMT7	EIF2S1
Description		protein arginine methyltransferase 7	eukaryotic translation initiation factor 2 subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytosol	Nucleus Cytosol Polysome Eukaryotic Translation Initiation Factor 2 Complex Eukaryotic Translation Initiation Factor 2B Complex Cytoplasmic Stress Granule Membrane Eukaryotic 48S Preinitiation Complex Multi-eIF Complex Translation Initiation Ternary Complex Synapse Extracellular Exosome Glial Limiting End-foot
	Molecular Function	Protein Binding Histone-arginine N-methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity [myelin Basic Protein]-arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific)	RNA Binding Translation Initiation Factor Activity Protein Binding Ribosome Binding
	Biological Process	Spliceosomal SnRNP Assembly Regulation Of Gene Expression By Genetic Imprinting Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Cell Differentiation Histone Arginine Methylation DNA Methylation Involved In Gamete Generation Regulation Of Protein Binding Histone H4-R3 Methylation	Translational Initiation Aging Negative Regulation Of Translational Initiation In Response To Stress Stress Granule Assembly Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To UV Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Protein Autophosphorylation Transmembrane Transport Positive Regulation Of Neuron Death Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		RMTs methylate histone arginines	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 28892062 25673413) Magnesium levels ( 20700443) Offspring birth weight ( 31043758) Schizophrenia ( 31579629) Serum metabolite levels ( 23093944) Weight ( 28552196)
Interacting Genes		11 interacting genes: CTCFL DIO3 EIF2S1 H2AC20 H3-5 H3C1 H4C1 MNDA POT1 SNRPB ZBTB24	24 interacting genes: CASP3 CASP6 CDC37 CSNK2A1 EIF1AX EIF2AK1 EIF2AK2 EIF2AK3 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2S2 HSP90AA1 HSPB1 MELK P4HB PPP1R15A PRKCA PRKCD PRMT7 SFN TERT THAP12
Entrez ID		54496	1965
HPRD ID		15174	04881
Ensembl ID		ENSG00000132600	ENSG00000134001
Uniprot IDs		A0A024R6Z2 A0A024R726 Q9NVM4	P05198 Q53XC0
PDB IDs			1KL9 1Q8K 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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