POLR2B and LZTR1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		POLR2B	LZTR1
Description		RNA polymerase II subunit B	leucine zipper like transcription regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm RNA Polymerase II, Core Complex Membrane	Golgi Apparatus Endomembrane System Cul3-RING Ubiquitin Ligase Complex Recycling Endosome Membrane
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Ribonucleoside Binding Metal Ion Binding	DNA-binding Transcription Factor Activity Ras GTPase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription-coupled Nucleotide-excision Repair Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Somatic Stem Cell Population Maintenance SnRNA Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Regulation Of Gene Silencing By MiRNA	Regulation Of Transcription, DNA-templated Anatomical Structure Morphogenesis Protein Ubiquitination Negative Regulation Of Ras Protein Signal Transduction
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Age-related macular degeneration ( 21909106) Bitter alcoholic beverage consumption ( 31046077) Congenital heart disease (maternal effect) ( 28468790) Coronary artery disease ( 29212778) Height ( 20881960 25429064) Metabolite levels ( 23823483) White blood cell count ( 29403010)
Interacting Genes		19 interacting genes: BTF3 CALM1 CCNH CDK7 CTDP1 IKBKG ITCH LZTR1 MEN1 NEDD4 OTUD5 POLR2C POLR2D POLR2H POLR2K POLR2L SNAR-B2 SUB1 ZSCAN1	54 interacting genes: AATF ANKRD53 ASB12 BMPR1B CEBPZ CHAF1A CNOT6L E2F8 EHMT1 FANK1 HCLS1 HDAC4 HRAS IKBKG KDM2B KRAS L3MBTL3 MCM3 MED16 MED7 MRAS MYBL2 NR1H3 NRAS PAPOLG PARP1 POLR1B POLR2B POLR2E RAI1 RERE RUVBL1 SCMH1 SND1 SP100 SREBF2 SSX4 STAT1 SUGP2 TAF11 TBX2 TCF19 TFAP2B TRIM5 TUBGCP4 WWP1 ZBTB1 ZNF137P ZNF175 ZNF451 ZNF490 ZNF584 ZNF714 ZZZ3
Entrez ID		5431	8216
HPRD ID		15943	08992
Ensembl ID		ENSG00000047315	ENSG00000099949
Uniprot IDs		A0A1W2PPT5 B4DH29 B4DHJ3 C9J2Y9 P30876	A0A384NL67 Q8N653
PDB IDs		5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L
Enriched GO Terms of Interacting Partners?
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