SERPINE2 and COL4A5

Number of citations of the paper that reports this interaction (PubMedID 8006028)
5

Data Source:
HPRD (in vivo)

		SERPINE2	COL4A5
Description		serpin family E member 2	collagen type IV alpha 5 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Extrinsic Component Of External Side Of Plasma Membrane Neuromuscular Junction Collagen-containing Extracellular Matrix Extracellular Vesicle	Extracellular Region Collagen Type IV Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cerebellar Granular Layer Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs
Drugs
Diseases			Alport syndrome
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Blood protein levels ( 30072576 29875488) Cerebrospinal T-tau levels ( 28247064) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Height ( 20881960 31562340) Mean platelet volume ( 27863252) Platelet-derived growth factor BB levels ( 27989323)
Interacting Genes		8 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 FAM9B	19 interacting genes: ANTXR2 ANXA7 APP CD93 CDKN1A DAZAP2 DCN FBLN2 FN1 GLA HABP2 MATN2 MMP9 NR1H2 OSM RNF10 SERPINE2 SMN1 TK1
Entrez ID		5270	1287
HPRD ID		01510	02363
Ensembl ID		ENSG00000135919	ENSG00000188153
Uniprot IDs		A0A024R451 A0A024R498 P07093	A7MBN3 P29400 Q49AM6
PDB IDs		4DY0 4DY7	5NAZ
Enriched GO Terms of Interacting Partners?
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