ABCB1 and RNF2

Number of citations of the paper that reports this interaction (PubMedID 17088979)
7

Data Source:
HPRD (in vivo, two hybrid)

		ABCB1	RNF2
Description		ATP binding cassette subfamily B member 1	ring finger protein 2
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Extracellular Exosome External Side Of Apical Plasma Membrane	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Transporter Activity Protein Binding ATP Binding Xenobiotic Transmembrane Transporting ATPase Activity Efflux Transmembrane Transporter Activity ATPase Activity Ubiquitin Protein Ligase Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity Phosphatidylcholine-translocating ATPase Activity Phosphatidylethanolamine-translocating ATPase Activity Ceramide-translocating ATPase Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Response To Drug Phospholipid Translocation Regulation Of Response To Osmotic Stress Transmembrane Transport Transepithelial Transport Stem Cell Proliferation Ceramide Translocation Export Across Plasma Membrane Positive Regulation Of Anion Channel Activity Drug Transport Across Blood-brain Barrier Regulation Of Chloride Transport	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Germ Cell Development Anterior/posterior Axis Specification Gene Expression Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of G0 To G1 Transition
Pathways		Abacavir transmembrane transport ABC-family proteins mediated transport	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs		ATP Roxithromycin Voacamine Elacridar Tesmilifene FM-VP4 Miltefosine
Diseases
GWAS		Bone mineral density (spine) and age at menarche ( 26312577) Gallbladder cancer ( 28274756) Neurological blood protein biomarker levels ( 31320639)	Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		11 interacting genes: BCCIP CAV1 CD4 HAX1 LNX1 MAPKAP1 MAPRE1 NEDD4 PIM1 PSMB8 RNF2	55 interacting genes: ABCB1 AMBRA1 AUTS2 BAALC BMI1 CASP3 CASP9 CBX2 CBX4 ERG H2AC18 H2AC20 H2AC4 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SIK1 SMURF2 SSX2 TARDBP TFCP2 TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W USP11 USP19 WASHC1
Entrez ID		5243	6045
HPRD ID		01370	07028
Ensembl ID		ENSG00000085563	ENSG00000121481
Uniprot IDs		A4D1D2 P08183	Q99496
PDB IDs		6C0V 6FN1 6FN4 6QEX	2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O
Enriched GO Terms of Interacting Partners?
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