PGGT1B and RRAS2

Number of citations of the paper that reports this interaction (PubMedID 15451670)
85

Data Source:
HPRD (in vitro)

		PGGT1B	RRAS2
Description		protein geranylgeranyltransferase type I subunit beta	RAS related 2
Image		No pdb structure
GO Annotations	Cellular Component	CAAX-protein Geranylgeranyltransferase Complex	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Drug Binding Zinc Ion Binding Isoprenoid Binding Peptide Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Positive Regulation Of Cell Proliferation Protein Prenylation Protein Geranylgeranylation Response To Cytokine Positive Regulation Of Cell Cycle Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways
Drugs		4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE Geranylgeranyl diphosphate 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATE
Diseases
GWAS		Longevity ( 30294719)	Alzheimer's disease (cognitive decline) ( 23535033) Height ( 31562340) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Vitamin D levels ( 25208829)
Interacting Genes		5 interacting genes: CDC42 GNG2 KRAS RHOB RRAS2	29 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		5229	22800
HPRD ID		03612	02518
Ensembl ID		ENSG00000164219	ENSG00000133818
Uniprot IDs		P53609	P62070
PDB IDs			2ERY
Enriched GO Terms of Interacting Partners?
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