PDK3 and PDHA1

Number of citations of the paper that reports this interaction (PubMedID 12676647)
138

Data Source:
HPRD (in vitro)

		PDK3	PDHA1
Description		pyruvate dehydrogenase kinase 3	pyruvate dehydrogenase E1 subunit alpha 1
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GO Annotations	Cellular Component	Cell Nucleolus Mitochondrion Mitochondrial Matrix	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Glucose Metabolic Process Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Peptidyl-serine Phosphorylation Peroxisome Proliferator Activated Receptor Signaling Pathway Glucose Homeostasis Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Pyruvate Dehydrogenase Activity Regulation Of Reactive Oxygen Species Metabolic Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid	Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		Radicicol Dihydrolipoic Acid	NADH
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS			Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: APP DLAT EGFR PDHA1	9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		5165	5160
HPRD ID		03956	02420
Ensembl ID		ENSG00000067992	ENSG00000131828
Uniprot IDs		Q15120	A0A024RBX9 P08559
PDB IDs		1Y8N 1Y8O 1Y8P 2PNR 2Q8I	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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