PDHA1 and PDP1

Number of citations of the paper that reports this interaction (PubMedID 7782287)
28

Data Source:
HPRD (in vitro)

		PDHA1	PDP1
Description		pyruvate dehydrogenase E1 subunit alpha 1	pyruvate dehyrogenase phosphatase catalytic subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism	Regulation of pyruvate dehydrogenase (PDH) complex
Drugs		NADH
Diseases		Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome	Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1	8 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 PDHA1 PLEKHF2 PRKCD SIRT3
Entrez ID		5160	54704
HPRD ID		02420	16185
Ensembl ID		ENSG00000131828	ENSG00000164951
Uniprot IDs		A0A024RBX9 P08559	A0A024R9C0 Q6P1N1 Q9P0J1
PDB IDs		1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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