PHF7 and RNF111

Number of citations of the paper that reports this interaction (PubMedID 22493164)
5

Data Source:
BioGRID (two hybrid)

		PHF7	RNF111
Description		PHD finger protein 7	ring finger protein 111
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair
Pathways			Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)
Interacting Genes		16 interacting genes: APP ARIH2 DTX3L H3-4 IKBKG MAGEF1 MDM2 RNF111 RNF14 RNF34 SRPK1 TRIM26 TRIM41 UBE2D4 USP1 USP15	44 interacting genes: ACTN3 ANAPC11 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD FBN1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W
Entrez ID		51533	54778
HPRD ID		15127	09318
Ensembl ID		ENSG00000010318	ENSG00000157450
Uniprot IDs		A0A024R336 A8K856 Q9BWX1	A0A024R5T5 Q6ZNA4
PDB IDs			2KIZ 5LG0 5LG7
Enriched GO Terms of Interacting Partners?
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