PDE9A and LMO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PDE9A	LMO2
Description		phosphodiesterase 9A	LIM domain only 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Cytosol Ruffle Membrane Sarcolemma Perikaryon Perinuclear Region Of Cytoplasm	Nucleoplasm Transcription Factor Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding BHLH Transcription Factor Binding Metal Ion Binding Cofactor Binding E-box Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP-mediated Signaling CGMP Metabolic Process CGMP Catabolic Process	Multicellular Organism Development MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Thyroid Hormone Stimulus Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		cGMP effects	RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs		Caffeine Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Perceived unattractiveness to mosquitoes ( 28199695)	Cognitive performance ( 19734545) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		20 interacting genes: BAG3 C9orf106 CLK1 CRY2 GORASP2 KRTAP10-3 KRTAP10-8 KRTAP4-2 KRTAP9-2 LAGE3 LMO2 NAA38 NOTCH2NLA PCNT PHYHIPL SULT1E1 TFAP4 TRIM32 TRPV6 UTP23	97 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 ALDH6A1 AXIN1 BANP BEX2 BLZF1 C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DRAP1 EHMT2 ELF2 ERBIN FHL3 GATA1 GATA2 GATA3 GFAP GOLGA2 GRB2 HNRNPC HNRNPM HOOK1 IFT43 IHO1 IKZF3 ISL1 KANK2 KDM5A KIF3B KRT15 KRT40 KRTAP10-7 LDB1 LYL1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MRFAP1L1 MTUS2 N4BP2L2 NCAPH2 NHLH1 NIF3L1 NOTCH2NLA NUP62 NUTM1 PDE9A PHC2 PRKG1 RBBP8 REL RELA RINT1 RLIM ROCK1 SAXO1 SKP1 SMAD2 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TFPT TLE5 TLX3 TRIM23 TRIM54 TRIP6 TSC22D4 TUFT1 UBA6 UBE2I ZFP64 ZNF24
Entrez ID		5152	4005
HPRD ID		09115	01586
Ensembl ID		ENSG00000160191	ENSG00000135363
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	P25791
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N	2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?
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