PRRX2 and SOX10

Number of citations of the paper that reports this interaction (PubMedID 16582099)
57

Data Source:
HPRD (two hybrid)

		PRRX2	SOX10
Description		paired related homeobox 2	SRY-box transcription factor 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Nuclear Chromatin Nucleus Nucleoplasm Extrinsic Component Of Mitochondrial Outer Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Positive Regulation Of Neuroblast Proliferation Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Peripheral Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Schwann Cell Proliferation Oligodendrocyte Development Positive Regulation Of Gliogenesis Central Nervous System Myelination Melanocyte Differentiation Positive Regulation Of Myelination Lacrimal Gland Development Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Enteric Nervous System Development Digestive Tract Morphogenesis Developmental Growth Oligodendrocyte Differentiation Morphogenesis Of A Branching Epithelium Cellular Response To Progesterone Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Waardenburg syndrome (WS)
GWAS		Response to exercise (triglyceride level interaction) ( 26491034)
Interacting Genes		2 interacting genes: NUP214 SOX10	29 interacting genes: ALX4 CDK6 CEBPA DLX5 EGR2 EXOC5 GSK3B HHEX HIVEP1 HOXA3 HOXC4 JUN MEOX1 NMI OLIG2 PAX3 PAX6 POU3F2 POU3F3 POU5F1 PRRX1 PRRX2 SP1 SUMO1 SUMO2 SUMO3 TCF12 UBE2I UTF1
Entrez ID		51450	6663
HPRD ID		05244	03752
Ensembl ID		ENSG00000167157	ENSG00000100146
Uniprot IDs		A0A140VJS2 Q99811	A0A024R1N6 P56693
PDB IDs
Enriched GO Terms of Interacting Partners?
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