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SOX10
Description
SRY-box transcription factor 10
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromatin
Nucleus
Nucleoplasm
Extrinsic Component Of Mitochondrial Outer Membrane
Molecular Function
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Transcription Coactivator Activity
Protein Binding
Transcription Factor Binding
Identical Protein Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Neural Crest Cell Migration
Morphogenesis Of An Epithelium
Positive Regulation Of Neuroblast Proliferation
Regulation Of Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
Peripheral Nervous System Development
Anatomical Structure Morphogenesis
Negative Regulation Of Schwann Cell Proliferation
Oligodendrocyte Development
Positive Regulation Of Gliogenesis
Central Nervous System Myelination
Melanocyte Differentiation
Positive Regulation Of Myelination
Lacrimal Gland Development
Negative Regulation Of Apoptotic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Maturation
Enteric Nervous System Development
Digestive Tract Morphogenesis
Developmental Growth
Oligodendrocyte Differentiation
Morphogenesis Of A Branching Epithelium
Cellular Response To Progesterone Stimulus
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
Waardenburg syndrome (WS)
GWAS
Interacting Genes
29 interacting genes:
ALX4
CDK6
CEBPA
DLX5
EGR2
EXOC5
GSK3B
HHEX
HIVEP1
HOXA3
HOXC4
JUN
MEOX1
NMI
OLIG2
PAX3
PAX6
POU3F2
POU3F3
POU5F1
PRRX1
PRRX2
SP1
SUMO1
SUMO2
SUMO3
TCF12
UBE2I
UTF1
Entrez ID
6663
HPRD ID
03752
Ensembl ID
ENSG00000100146
Uniprot IDs
A0A024R1N6
P56693
PDB IDs
Enriched GO Terms of Interacting Partners
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