PDE4C and GDF15

		PDE4C	GDF15
Description		phosphodiesterase 4C	growth differentiation factor 15
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GO Annotations	Cellular Component	Extracellular Space Cytosol Cilium	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	CAMP Catabolic Process G Protein-coupled Receptor Signaling Pathway	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion
Pathways		DARPP-32 events G alpha (s) signalling events
Drugs		Caffeine Dyphylline Iloprost Roflumilast Piclamilast Crisaborole Ibudilast Trapidil
Diseases
GWAS		Urate levels ( 31578528)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		2 interacting genes: GDF15 SRI	16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1
Entrez ID		5143	9518
HPRD ID		02529	05608
Ensembl ID		ENSG00000105650	ENSG00000130513
Uniprot IDs		O43849 P78505 Q08493 Q32MM7 Q7KYS4	Q99988
PDB IDs		1LXU 2QYM	5VT2 5VZ3 5VZ4 6Q2J
Enriched GO Terms of Interacting Partners?
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