GDF15 and SULT2A1

		GDF15	SULT2A1
Description		growth differentiation factor 15	sulfotransferase family 2A member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Collagen-containing Extracellular Matrix Extracellular Exosome	Cytosol
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity	Protein Binding Sulfotransferase Activity Bile-salt Sulfotransferase Activity Steroid Sulfotransferase Activity
	Biological Process	Activation Of MAPK Activity Reduction Of Food Intake In Response To Dietary Excess Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase B Signaling SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion	Ethanol Catabolic Process Steroid Metabolic Process Lipid Catabolic Process Regulation Of Lipid Metabolic Process Bile Acid Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways			Cytosolic sulfonation of small molecules PPARA activates gene expression
Drugs			Prasterone Adenosine-3'-5'-Diphosphate Aetiocholanolone Mercuric iodide
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Coffee consumption ( 31046077) Growth differentiation factor-15 levels ( 29628937) Hyperemesis gravidarum ( 29563502) Severity of nausea and vomiting of pregnancy ( 29563502)	Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Blood protein levels ( 30072576) Cleft palate ( 30452639) Dehydroepiandrosterone sulphate levels ( 21533175) Gallstone disease ( 30504769 27094239) Serum metabolite levels ( 23093944) Sex hormone levels ( 26014426) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		16 interacting genes: ALOX5AP BORCS8-MEF2B C19orf57 COPE EHF FCHO1 HOMER3 IL27RA MAPK14 MAST3 MDFI MED26 NLGN3 PDE4C SIN3B SULT2A1	6 interacting genes: GDF15 PRDX4 STAT3 STK3 SULT1B1 TMX1
Entrez ID		9518	6822
HPRD ID		05608	00502
Ensembl ID		ENSG00000130513	ENSG00000105398
Uniprot IDs		Q99988	A8K015 Q06520
PDB IDs		5VT2 5VZ3 5VZ4 6Q2J	1EFH 1J99 1OV4 2QP3 2QP4 3F3Y 4IFB
Enriched GO Terms of Interacting Partners?
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