PCSK5 and PMCH

Number of citations of the paper that reports this interaction (PubMedID 10037747)
7

Data Source:
HPRD (in vivo)

		PCSK5	PMCH
Description		proprotein convertase subtilisin/kexin type 5	pro-melanin concentrating hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane Secretory Granule Integral Component Of Golgi Membrane	Extracellular Region Nucleus Synapse
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Peptide Binding	Melanin-concentrating Hormone Activity Type 1 Melanin-concentrating Hormone Receptor Binding
	Biological Process	Kidney Development Renin Secretion Into Blood Stream Cardiac Septum Development Signal Peptide Processing Cell-cell Signaling Determination Of Left/right Symmetry Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Regulation Of Lipoprotein Lipase Activity Coronary Vasculature Development	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Spermatogenesis Behavior Feeding Behavior Cell Differentiation
Pathways		NGF processing Assembly of active LPL and LIPC lipase complexes	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 28552196 20881960 25282103 23563607 31562340) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 29785010 31959993 30054594) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Adventurousness ( 30643258) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 19893584) Number of sexual partners ( 30643258)
Interacting Genes		19 interacting genes: AMH APPBP2 ATN1 CACNA1A GLRX3 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NLA NUFIP2 PMCH PTPRM REN STK16	10 interacting genes: CPE FURIN MCHR1 MCHR2 NPY PCSK1 PCSK2 PCSK5 PCSK6 PCSK7
Entrez ID		5125	5367
HPRD ID		08985	01459
Ensembl ID		ENSG00000099139	ENSG00000183395
Uniprot IDs		Q92824	P20382
PDB IDs
Enriched GO Terms of Interacting Partners?
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