ACOX1 and SCP2

Number of citations of the paper that reports this interaction (PubMedID 10856712)
27

Data Source:
HPRD (in vitro)

		ACOX1	SCP2
Description		acyl-CoA oxidase 1	sterol carrier protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Nucleoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Acyl-CoA Oxidase Activity Fatty Acid Binding Palmitoyl-CoA Oxidase Activity PDZ Domain Binding Protein N-terminus Binding Flavin Adenine Dinucleotide Binding FAD Binding	Fatty-acyl-CoA Binding Signaling Receptor Binding Protein Binding Cholesterol Binding Sterol Binding Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Oleic Acid Binding
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Generation Of Precursor Metabolites And Energy Protein Targeting To Peroxisome Lipid Metabolic Process Prostaglandin Metabolic Process Spermatogenesis Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Lipid Homeostasis	Protein Targeting To Peroxisome Steroid Biosynthetic Process Bile Acid Biosynthetic Process Phospholipid Transport Positive Regulation Of Intracellular Cholesterol Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Lipid Hydroperoxide Transport
Pathways		Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Flavin adenine dinucleotide (3R)-3-HYDROXYDODECANOIC ACID
Diseases		Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia	Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia Leukoencephalopathy with dystonia and motor neuropathy
GWAS		Body mass index ( 28552196) Diastolic blood pressure ( 27841878) Pulse pressure ( 27841878) Systolic blood pressure ( 28135244 27841878) Urinary metabolite levels in chronic kidney disease ( 31959995) White matter hyperintensity burden ( 25663218)
Interacting Genes		3 interacting genes: SCP2 SLC2A4 TYSND1	9 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CREB3 EHHADH PEX5 PITPNA TRIP13
Entrez ID		51	6342
HPRD ID		02030	01700
Ensembl ID		ENSG00000161533	ENSG00000116171
Uniprot IDs		Q15067	A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9
PDB IDs			1QND 2C0L
Enriched GO Terms of Interacting Partners?
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