PC and GOT1

Number of citations of the paper that reports this interaction (PubMedID 8349677)
3

Data Source:
BioGRID (pull down)

		PC	GOT1
Description		pyruvate carboxylase	glutamic-oxaloacetic transaminase 1
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol	Cell Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Exosome
	Molecular Function	Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity
	Biological Process	Pyruvate Metabolic Process Gluconeogenesis Lipid Metabolic Process Biotin Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Cellular Amino Acid Biosynthetic Process Response To Carbohydrate Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus Response To Transition Metal Nanoparticle
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis	Methionine salvage pathway Gluconeogenesis Aspartate and asparagine metabolism
Drugs		Pyruvic acid Biotin 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL	Pyridoxal Phosphate L-Aspartic Acid Glutamic Acid L-Cysteine Maleic Acid Copper
Diseases		Pyruvate carboxylase deficiency
GWAS		Bipolar disorder ( 21926972 31043756) Familial squamous cell lung carcinoma ( 29924316) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528)	Aspartate aminotransferase levels ( 30718733 21900944) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010)
Interacting Genes		3 interacting genes: GOT1 GOT2 MDH2	4 interacting genes: ABI3BP EGFR PC TMEM120A
Entrez ID		5091	2805
HPRD ID		02032	00687
Ensembl ID		ENSG00000173599	ENSG00000120053
Uniprot IDs		A0A024R5C5 P11498	A0A140VK69 P17174
PDB IDs		3BG3 3BG9	3II0 3WZF 6DNA 6DNB 6DND
Enriched GO Terms of Interacting Partners?
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