GOT1 and ABI3BP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GOT1	ABI3BP
Description		glutamic-oxaloacetic transaminase 1	ABI family member 3 binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Axon Terminus Extracellular Exosome	Extracellular Region Interstitial Matrix Extracellular Space Collagen-containing Extracellular Matrix
	Molecular Function	L-aspartate:2-oxoglutarate Aminotransferase Activity Phosphatidylserine Decarboxylase Activity Pyridoxal Phosphate Binding Carboxylic Acid Binding L-cysteine:2-oxoglutarate Aminotransferase Activity	Extracellular Matrix Structural Constituent Collagen Binding Heparin Binding
	Biological Process	Gluconeogenesis 2-oxoglutarate Metabolic Process Oxaloacetate Metabolic Process Glycerol Biosynthetic Process Aspartate Metabolic Process Aspartate Biosynthetic Process Aspartate Catabolic Process Glutamate Metabolic Process Notch Signaling Pathway Cellular Amino Acid Biosynthetic Process Response To Carbohydrate Glutamate Catabolic Process To Aspartate Glutamate Catabolic Process To 2-oxoglutarate Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Collagen Biosynthetic Process Response To Immobilization Stress Response To Cadmium Ion Response To Glucocorticoid Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Fatty Acid Homeostasis Transdifferentiation Cellular Response To Mechanical Stimulus Response To Transition Metal Nanoparticle	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization
Pathways		Methionine salvage pathway Gluconeogenesis Aspartate and asparagine metabolism
Drugs		Pyridoxal Phosphate L-Aspartic Acid Glutamic Acid L-Cysteine Maleic Acid Copper
Diseases
GWAS		Aspartate aminotransferase levels ( 30718733 21900944) Crohn's disease ( 22412388) Hypothyroidism ( 27182965) Liver enzyme levels (aspartate transaminase) ( 24124411) Mean corpuscular volume ( 29403010)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Alcohol dependence ( 26365420) Asthma (childhood onset) ( 23829686) Carotid plaque burden ( 28282560) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Joint mobility (Beighton score) ( 27182965) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 28073927) Optic disc size ( 31809533) Post bronchodilator FEV1 in COPD ( 26634245) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		4 interacting genes: ABI3BP EGFR PC TMEM120A	6 interacting genes: ABI3 CBX1 FZD5 GOT1 GRB2 MBNL1
Entrez ID		2805	25890
HPRD ID		00687	09380
Ensembl ID		ENSG00000120053	ENSG00000154175
Uniprot IDs		A0A140VK69 P17174	D3YTG3 Q7Z7G0
PDB IDs		3II0 3WZF 6DNA 6DNB 6DND
Enriched GO Terms of Interacting Partners?
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