P2RX7 and SVIL

Number of citations of the paper that reports this interaction (PubMedID 11707406)
117

Data Source:
HPRD (in vivo)

		P2RX7	SVIL
Description		purinergic receptor P2X 7	supervillin
Image		No pdb structure
GO Annotations	Cellular Component	Cell Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Presynapse Postsynapse	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Costamere Invadopodium
	Molecular Function	Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding	Protein Binding Actin Filament Binding
	Biological Process	Activation Of MAPK Activity Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Response To Ischemia Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Vesicle Budding From Membrane Inflammatory Response Mitochondrion Organization Cell Surface Receptor Signaling Pathway Blood Coagulation Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Exocytosis Protein Processing Phospholipid Scrambling Sensory Perception Of Pain Protein Catabolic Process Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Response To Fluid Shear Stress Positive Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Purinergic Nucleotide Receptor Signaling Pathway T Cell Proliferation T Cell Homeostasis NAD Transport Negative Regulation Of MAPK Cascade Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-positive Bacterium Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Excitatory Postsynaptic Potential Positive Regulation Of Lymphocyte Apoptotic Process Calcium Ion Transmembrane Transport Cellular Response To ATP Cellular Response To DsRNA Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Bleb Assembly Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling	Cytoskeleton Organization Skeletal Muscle Tissue Development Positive Regulation Of Cytokinesis
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS		Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155)
Interacting Genes		9 interacting genes: ACTB CASK EFNB3 EMP3 KRT31 KRTAP10-8 PANX1 SVIL TM9SF1	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF14 KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		5027	6840
HPRD ID		03977	04992
Ensembl ID		ENSG00000089041	ENSG00000197321
Uniprot IDs		Q99572	O95425 Q569J5
PDB IDs			2K6M 2K6N
Enriched GO Terms of Interacting Partners?
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