P2RX7 and EFNB3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		P2RX7	EFNB3
Description		purinergic receptor P2X 7	ephrin B3
Image		No pdb structure
GO Annotations	Cellular Component	Cell Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Membrane Neuromuscular Junction Bleb Neuronal Cell Body Presynapse Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding	Virus Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Activation Of MAPK Activity Cell Morphogenesis Phagolysosome Assembly Positive Regulation Of T Cell Mediated Cytotoxicity Regulation Of Sodium Ion Transport Response To Ischemia Protein Phosphorylation Membrane Protein Ectodomain Proteolysis Phospholipid Transfer To Membrane Vesicle Budding From Membrane Inflammatory Response Mitochondrion Organization Cell Surface Receptor Signaling Pathway Blood Coagulation Response To Mechanical Stimulus Response To Zinc Ion Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Synaptic Vesicle Exocytosis Protein Processing Phospholipid Scrambling Sensory Perception Of Pain Protein Catabolic Process Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Collagen Metabolic Process Response To ATP Response To Fluid Shear Stress Positive Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Purinergic Nucleotide Receptor Signaling Pathway T Cell Proliferation T Cell Homeostasis NAD Transport Negative Regulation Of MAPK Cascade Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Ceramide Biosynthetic Process Pore Complex Assembly Skeletal System Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Interleukin-1 Alpha Secretion Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Gram-positive Bacterium Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytoskeleton Organization Response To Calcium Ion Response To Electrical Stimulus Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Positive Regulation Of Mitochondrial Depolarization Excitatory Postsynaptic Potential Positive Regulation Of Lymphocyte Apoptotic Process Calcium Ion Transmembrane Transport Cellular Response To ATP Cellular Response To DsRNA Reactive Oxygen Species Metabolic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Bleb Assembly Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Axon Choice Point Recognition T Cell Costimulation Viral Entry Into Host Cell Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)	Alcohol consumption ( 31358974)
Interacting Genes		9 interacting genes: ACTB CASK EFNB3 EMP3 KRT31 KRTAP10-8 PANX1 SVIL TM9SF1	8 interacting genes: AATF ELOC EPHA4 EPHB3 NUP88 P2RX7 RHBDL2 YWHAZ
Entrez ID		5027	1949
HPRD ID		03977	03804
Ensembl ID		ENSG00000089041	ENSG00000108947
Uniprot IDs		Q99572	Q15768
PDB IDs			4BKF
Enriched GO Terms of Interacting Partners?
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