OPRL1 and PNOC

Number of citations of the paper that reports this interaction (PubMedID 11097863)
15

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		OPRL1	PNOC
Description		opioid related nociceptin receptor 1	prepronociceptin
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection	Extracellular Region Plasma Membrane Dendrite Neuronal Cell Body Axon Terminus
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Protein C-terminus Binding Peptide Binding Neuropeptide Binding	Opioid Peptide Activity Neuropeptide Hormone Activity Opioid Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Sensory Perception Of Pain Response To Estradiol Positive Regulation Of Urine Volume Opioid Receptor Signaling Pathway Eating Behavior Estrous Cycle Negative Regulation Of Blood Pressure Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Gastric Acid Secretion Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Sensory Perception Of Pain Regulation Of Locomotor Rhythm Conditioned Place Preference	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Female Pregnancy Sensory Perception
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) LDL peak particle diameter (total fat intake interaction) ( 26112879) Mean corpuscular volume ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552)	Body mass index ( 28892062) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: GNA14 GPRASP1 PNOC RGS19	2 interacting genes: FBXO7 OPRL1
Entrez ID		4987	5368
HPRD ID		03971	03268
Ensembl ID		ENSG00000125510	ENSG00000168081
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	Q13519
PDB IDs		4EA3 5DHG 5DHH
Enriched GO Terms of Interacting Partners?
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