NPPB and NPR2

Number of citations of the paper that reports this interaction (PubMedID 1672777)
86

Data Source:
BioGRID (pull down)

		NPPB	NPR2
Description		natriuretic peptide B	natriuretic peptide receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Diuretic Hormone Activity Hormone Receptor Binding	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure CGMP Biosynthetic Process Protein Folding Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Regulation Of Vascular Permeability Regulation Of Blood Vessel Diameter	Ossification CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Meiotic Cell Cycle Bone Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Oocyte Maturation Regulation Of Cardiac Conduction
Pathways			Physiological factors
Drugs		Carvedilol Oxymetholone	Erythrityl Tetranitrate Nesiritide
Diseases			Acromesomelic dysplasia, Maroteaux type
GWAS		B-type natriuretic peptide levels ( 29237677 25561047) B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio ( 29237677) Blood pressure ( 21909110) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Diastolic blood pressure ( 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) N-terminal pro B-type natriuretic peptide levels ( 29237677) NT-proBNP levels in acute coronary syndrome ( 26908625) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 19430483 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Blood protein levels ( 28240269) Heel bone mineral density ( 30598549) Height ( 31562340)
Interacting Genes		10 interacting genes: EWSR1 HDAC4 KRT40 KRTAP10-3 KRTAP10-9 NOTCH2NLA NPR1 NPR2 NPR3 PSMA3	3 interacting genes: NPPA NPPB NPPC
Entrez ID		4879	4882
HPRD ID		08974	00166
Ensembl ID		ENSG00000120937	ENSG00000159899
Uniprot IDs		P16860	P20594
PDB IDs		1YK1 3N56
Enriched GO Terms of Interacting Partners?
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