NPR2 and NPPC

Number of citations of the paper that reports this interaction (PubMedID 1672777)
86

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NPR2	NPPC
Description		natriuretic peptide receptor 2	natriuretic peptide C
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex
	Molecular Function	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding Hormone Binding Identical Protein Binding	Signaling Receptor Binding Hormone Activity Hormone Receptor Binding
	Biological Process	Ossification CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Meiotic Cell Cycle Bone Development Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Oocyte Maturation Regulation Of Cardiac Conduction	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Proliferation Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Collagen Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Ethanol Positive Regulation Of Osteoblast Differentiation Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Oocyte Maturation Regulation Of Cardiac Conduction Negative Regulation Of DNA Biosynthetic Process
Pathways		Physiological factors	Physiological factors
Drugs		Erythrityl Tetranitrate Nesiritide
Diseases		Acromesomelic dysplasia, Maroteaux type
GWAS		Blood protein levels ( 28240269) Heel bone mineral density ( 30598549) Height ( 31562340)	Height ( 20881960 25282103 25429064 19570815 18391951) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		3 interacting genes: NPPA NPPB NPPC	4 interacting genes: MME NPR1 NPR2 NPR3
Entrez ID		4882	4880
HPRD ID		00166	08975
Ensembl ID		ENSG00000159899	ENSG00000163273
Uniprot IDs		P20594	E5LCN7 P23582
PDB IDs			1JDP
Enriched GO Terms of Interacting Partners?
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