ATP2A1 and IRS2

Number of citations of the paper that reports this interaction (PubMedID 9295312)
12

Data Source:
HPRD (in vivo, in vitro)

		ATP2A1	IRS2
Description		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	insulin receptor substrate 2
Image		No pdb structure
GO Annotations	Cellular Component	Cell Mitochondrion Endoplasmic Reticulum Membrane Integral Component Of Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Sarcoplasmic Reticulum Membrane Calcium Channel Complex	Cell Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Calcium-transporting ATPase Activity Calcium Ion Binding Protein Binding ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism Calcium-dependent ATPase Activity Protein Homodimerization Activity	Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding
	Biological Process	Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Mitochondrial Changes Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress Positive Regulation Of Mitochondrial Calcium Ion Concentration Maintenance Of Mitochondrion Location Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Import Calcium Ion Transmembrane Transport Relaxation Of Skeletal Muscle Positive Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Calcium-transporting ATPase Activity Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Proton Transmembrane Transport Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum	MAPK Cascade Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Axon Guidance Brain Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Glucose Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Interleukin-7-mediated Signaling Pathway Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Ras Protein Signal Transduction Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Kinase B Signaling Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling
Drugs		Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate Tetrafluoroaluminate Ion 2,5-DI-(TERT-BUTYL)-1,4,BENZOHYDROQUINONE (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE
Diseases		Brody myopathy
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 19079260 26961502 28892062 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cannabis use ( 30150663) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Type 2 diabetes ( 30297969) Waist circumference ( 31453325) Waist circumference variance ( 31453325) Weight ( 19079260)	Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Heel bone mineral density ( 30598549 28869591) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Reticulocyte fraction of red cells ( 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		4 interacting genes: IRS1 IRS2 PLN SLN	40 interacting genes: ATP2A1 ATP2A2 BCL2L1 CRK EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 MPL MTDH NEDD4 NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PTPN11 PTPN6 PTPRF RPTOR SHC1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		487	8660
HPRD ID		00157	02878
Ensembl ID		ENSG00000196296	ENSG00000185950
Uniprot IDs		O14983 Q7Z675	Q9P084 Q9Y4H2
PDB IDs			3FQW 3FQX
Enriched GO Terms of Interacting Partners?
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