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IRS2 and PTPN6
Number of citations of the paper that reports this interaction (PubMedID
12198247
)
11
Data Source:
HPRD
(in vivo)
IRS2
PTPN6
Description
insulin receptor substrate 2
protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations
Cellular Component
Cell
Cytosol
Plasma Membrane
Protein-containing Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cell-cell Junction
Membrane
Protein-containing Complex
Specific Granule Lumen
Alpha-beta T Cell Receptor Complex
Extracellular Exosome
Tertiary Granule Lumen
Molecular Function
Insulin Receptor Binding
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Phosphatidylinositol 3-kinase Binding
14-3-3 Protein Binding
Phosphotyrosine Residue Binding
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
SH2 Domain Binding
Cell Adhesion Molecule Binding
Phosphorylation-dependent Protein Binding
Biological Process
MAPK Cascade
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of B Cell Apoptotic Process
Glucose Metabolic Process
Signal Transduction
Axon Guidance
Brain Development
Positive Regulation Of Cell Proliferation
Insulin Receptor Signaling Pathway
Response To Glucose
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Regulation Of Lipid Metabolic Process
Positive Regulation Of Cell Migration
Mammary Gland Development
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Insulin Secretion
Cellular Response To Insulin Stimulus
Negative Regulation Of Kinase Activity
Interleukin-7-mediated Signaling Pathway
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glucose Import
Positive Regulation Of Ras Protein Signal Transduction
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Kinase B Signaling
Lipid Homeostasis
Cellular Response To Glucose Stimulus
Hematopoietic Progenitor Cell Differentiation
Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Protein Dephosphorylation
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Cell Differentiation
Platelet Activation
Platelet Formation
T Cell Costimulation
Negative Regulation Of Interleukin-6 Production
Negative Regulation Of Tumor Necrosis Factor Production
Abortive Mitotic Cell Cycle
Positive Regulation Of Cell Adhesion Mediated By Integrin
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Megakaryocyte Development
Negative Regulation Of T Cell Proliferation
Natural Killer Cell Mediated Cytotoxicity
Regulation Of Apoptotic Process
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of B Cell Differentiation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Type I Interferon-mediated Signaling Pathway
Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Cytokine Stimulus
Epididymis Development
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
PI3K Cascade
IRS-mediated signalling
SOS-mediated signalling
SOS-mediated signalling
PIP3 activates AKT signaling
Interleukin-7 signaling
PI3K/AKT activation
PI3K/AKT activation
Constitutive Signaling by Aberrant PI3K in Cancer
IRS-related events triggered by IGF1R
Signaling by Leptin
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
IRS activation
Signal attenuation
RET signaling
Signaling by Erythropoietin
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phospholipase C gamma (PLCG)
Erythropoietin activates STAT5
Erythropoietin activates RAS
Erythropoietin activates RAS
Growth hormone receptor signaling
GPVI-mediated activation cascade
Regulation of KIT signaling
PECAM1 interactions
Costimulation by the CD28 family
PD-1 signaling
Signal regulatory protein family interactions
Platelet sensitization by LDL
Interleukin-3, Interleukin-5 and GM-CSF signaling
CD22 mediated BCR regulation
Neutrophil degranulation
Interferon gamma signaling
Regulation of IFNG signaling
Interleukin-37 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS
Antipsychotic drug-induced weight gain in schizophrenia (
31447353
)
Heel bone mineral density (
30598549
28869591
)
Mean corpuscular hemoglobin (
29403010
27863252
)
Mean corpuscular volume (
29403010
27863252
)
Nose size (
27182965
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Platelet count (
29403010
)
Prostate cancer (
29117387
)
Reticulocyte fraction of red cells (
27863252
)
Type 2 diabetes (
30297969
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
White matter lesion progression (
26451028
)
White matter lesion progression (adjusted for white matter lesion burden at baseline) (
26451028
)
Mean corpuscular hemoglobin concentration (
29403010
)
Red blood cell fatty acid levels (
25500335
)
Interacting Genes
40 interacting genes:
ATP2A1
ATP2A2
BCL2L1
CRK
EPOR
FES
GRB2
IGF1R
IL4R
INSR
JAK1
JAK2
JAK3
MPL
MTDH
NEDD4
NTRK1
PIK3CA
PIK3CD
PIK3R1
PIK3R2
PIK3R3
PLCG1
PTPN11
PTPN6
PTPRF
RPTOR
SHC1
SOCS1
SOCS3
SOCS6
SOCS7
SRPK2
TYK2
UBTF
YWHAB
YWHAE
YWHAG
YWHAQ
YWHAZ
114 interacting genes:
AATK
ABL1
ACTN1
ACTN4
BCR
BLNK
BTLA
CAV1
CBL
CCDC88A
CD22
CD247
CD300LF
CD33
CD5
CD72
CD79A
CD79B
CDK1
CEACAM1
CLEC4A
CSF2RB
CTNNB1
CTNND1
CUZD1
CXCR4
DOK1
EGFR
EPOR
ERBB2
ERBB3
ERBB4
ESR1
FAS
FCGR2B
FCRL3
FGFR4
FHL3
FLT3
GAB2
GHR
GRB2
HOXA10
IFNAR1
IGF1R
IL2RB
IL4R
IL6ST
INSR
IRS2
IRS4
JAK1
JAK2
JAK3
KDR
KHDRBS1
KIR2DL3
KIR2DL5A
KIT
KLRA1P
KLRB1
KLRC1
LAIR1
LAT
LCK
LCP2
LIFR
LILRB2
LILRB4
LMTK2
LYN
MPIG6B
MS4A2
MYH9
NOS1
OLIG1
PAG1
PDGFRB
PECAM1
PIK3R1
PILRA
PILRB
PLCG2
PRKCA
PRKCD
PTK2B
PTK7
PTPN11
PTPRC
ROR1
ROR2
ROS1
SHC1
SIGLEC10
SIGLEC11
SIGLEC12
SIRPA
SLAMF6
SOS1
SPATA2
SRC
SSTR2
STAT5B
STAT6
SYK
TFG
TLR10
TMEM62
TNFRSF1A
TRAF6
TREML1
TYK2
VAV1
ZAP70
Entrez ID
8660
5777
HPRD ID
02878
01475
Ensembl ID
ENSG00000185950
ENSG00000111679
Uniprot IDs
Q9P084
Q9Y4H2
P29350
Q53XS4
PDB IDs
3FQW
3FQX
1FPR
1GWZ
1X6C
2B3O
2RMX
2YU7
3PS5
4GRY
4GRZ
4GS0
4HJP
4HJQ
Enriched GO Terms of Interacting Partners
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