NOTCH3 and TNNT2

Number of citations of the paper that reports this interaction (PubMedID 25356737)
12

Data Source:
BioGRID (pull down)

		NOTCH3	TNNT2
Description		notch receptor 3	troponin T2, cardiac type
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Actin Binding Calcium Ion Binding Protein Binding Tropomyosin Binding Troponin C Binding Calcium-dependent ATPase Activity Troponin I Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Forebrain Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Glomerular Capillary Formation	Skeletal Muscle Contraction Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3	Striated Muscle Contraction
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)	Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Pulse pressure ( 27841878 30578418)	Cardiac Troponin-T levels ( 23247143) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		43 interacting genes: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 UPF1 WDR25 XKR8	11 interacting genes: APP KDM1A MAP3K5 MORF4L2 MST1 NOTCH3 PRKCA TNNC1 TNNI1 TNNI3 TPM1
Entrez ID		4854	7139
HPRD ID		02607	01844
Ensembl ID		ENSG00000074181	ENSG00000118194
Uniprot IDs		Q9UM47	A0A0A0MRJ5 P45379 Q15607
PDB IDs		4ZLP 5CZV 5CZX	1J1D 1J1E 4Y99
Enriched GO Terms of Interacting Partners?
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