TNNT2 and TNNC1

Number of citations of the paper that reports this interaction (PubMedID 12840750)
276

Data Source:
BioGRID (two hybrid)
HPRD (in vitro)

		TNNT2	TNNC1
Description		troponin T2, cardiac type	troponin C1, slow skeletal and cardiac type
Image
GO Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Cytosol Troponin Complex Cardiac Troponin Complex
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Tropomyosin Binding Troponin C Binding Calcium-dependent ATPase Activity Troponin I Binding	Calcium Ion Binding Protein Binding Troponin I Binding Troponin T Binding Protein Homodimerization Activity Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Skeletal Muscle Contraction Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Diaphragm Contraction Skeletal Muscle Contraction Regulation Of Muscle Contraction Response To Metal Ion Transition Between Fast And Slow Fiber Muscle Filament Sliding Regulation Of Muscle Filament Sliding Speed Regulation Of ATPase Activity Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Striated Muscle Contraction	Striated Muscle Contraction
Drugs			Trifluoperazine Levosimendan Felodipine Bepridil Calcium Aluminium monostearate 5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases		Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Cardiac Troponin-T levels ( 23247143) Height ( 28552196) Neurofibrillary tangles ( 25188341)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Feeling worry ( 29500382) Schizophrenia ( 23974872)
Interacting Genes		11 interacting genes: APP KDM1A MAP3K5 MORF4L2 MST1 NOTCH3 PRKCA TNNC1 TNNI1 TNNI3 TPM1	12 interacting genes: CDK1 MST1 POLR2G RBM15B TCP10L TNNI1 TNNI2 TNNI3 TNNT1 TNNT2 TRIM63 UBE2C
Entrez ID		7139	7134
HPRD ID		01844	08930
Ensembl ID		ENSG00000118194	ENSG00000114854
Uniprot IDs		A0A0A0MRJ5 P45379 Q15607	P63316 Q6FH91
PDB IDs		1J1D 1J1E 4Y99	1AP4 1IH0 1J1D 1J1E 1LXF 1MXL 1OZS 1SPY 1WRK 1WRL 2JT0 2JT3 2JT8 2JTZ 2JXL 2KDH 2KFX 2KGB 2KRD 2L1R 2L98 2MKP 2MLE 2MLF 2MZP 2N79 2N7L 3RV5 3SD6 3SWB 4GJE 4GJF 4GJG 4Y99 5VLN 5W88 5WCL 6MV3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?