NOP2 and PTPRJ

Number of citations of the paper that reports this interaction (PubMedID 12370829)
26

Data Source:
HPRD (in vivo, in vitro)

		NOP2	PTPRJ
Description		NOP2 nucleolar protein	protein tyrosine phosphatase receptor type J
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Ruffle Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding RRNA (cytosine-C5-)-methyltransferase Activity	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding
	Biological Process	Ribosomal Large Subunit Assembly Maturation Of LSU-rRNA RNA Methylation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Proliferation RRNA Base Methylation Regulation Of Signal Transduction By P53 Class Mediator	Protein Dephosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion B Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways		rRNA modification in the nucleus and cytosol TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 22076464) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) Hypertension ( 31879980) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 29235454) Offspring birth weight ( 31043758) Sleep duration (short sleep) ( 30846698)
Interacting Genes		10 interacting genes: CDCA7L CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ SUMO2 UBE2I VPS52	20 interacting genes: BAP1 CASC3 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 HOXC6 IL2RG JUP KLK7 KLK9 LAT LYPD3 MET NOP2 PDGFRB PLCG1 PRDM14 SDCBP
Entrez ID		4839	5795
HPRD ID		01244	02955
Ensembl ID		ENSG00000111641	ENSG00000149177
Uniprot IDs		P46087	Q12913 Q9NPR5
PDB IDs			2CFV 2DLE 2NZ6
Enriched GO Terms of Interacting Partners?
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