PTPRJ and KLK7

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		PTPRJ	KLK7
Description		protein tyrosine phosphatase receptor type J	kallikrein related peptidase 7
Image
GO Annotations	Cellular Component	Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Ruffle Membrane Specific Granule Membrane Extracellular Exosome	Extracellular Region Extracellular Space Secretory Granule Epidermal Lamellar Body
	Molecular Function	Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity
	Biological Process	Protein Dephosphorylation Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion B Cell Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Protein Kinase B Signaling Contact Inhibition Positive Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Positive Regulation Of Antibacterial Peptide Production Proteolysis Epidermis Development Extracellular Matrix Disassembly
Pathways		Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity	Degradation of the extracellular matrix
Drugs			L-alanyl-N-[(1S,2R)-1-benzyl-2-hydroxypropyl]-L-alaninamide
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) Hypertension ( 31879980) Intraocular pressure ( 29617998 25173106 31798171 29785010 31959993 30054594 29235454) Offspring birth weight ( 31043758) Sleep duration (short sleep) ( 30846698)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		20 interacting genes: BAP1 CASC3 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 HOXC6 IL2RG JUP KLK7 KLK9 LAT LYPD3 MET NOP2 PDGFRB PLCG1 PRDM14 SDCBP	10 interacting genes: APP BAG4 CCND1 CDSN CHEK2 PTPN1 PTPRJ STK11 TGFB1 WT1
Entrez ID		5795	5650
HPRD ID		02955	05115
Ensembl ID		ENSG00000149177	ENSG00000169035
Uniprot IDs		Q12913 Q9NPR5	A0A024R4H6 B4DHX9 P49862
PDB IDs		2CFV 2DLE 2NZ6	2QXG 2QXH 2QXI 2QXJ 3BSQ 5FAH 5Y9L 5YJK
Enriched GO Terms of Interacting Partners?
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