NKX2-2 and OLIG2

Number of citations of the paper that reports this interaction (PubMedID 14573534)
26

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		NKX2-2	OLIG2
Description		NK2 homeobox 2	oligodendrocyte transcription factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Transcription Factor Binding Sequence-specific DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Identical Protein Binding Protein Dimerization Activity HMG Box Domain Binding
	Biological Process	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Smoothened Signaling Pathway Brain Development Response To Glucose Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Ventral Spinal Cord Interneuron Fate Determination	Negative Regulation Of Transcription By RNA Polymerase II Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Thalamus Development Myelination Negative Regulation Of Neuron Differentiation Neuron Fate Commitment Positive Regulation Of Oligodendrocyte Differentiation
Pathways		Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725)	Bulimia nervosa ( 23568457) Gastroesophageal reflux disease ( 31527586) Tea consumption ( 31046077)
Interacting Genes		1 interacting genes: OLIG2	5 interacting genes: CUL3 EP300 NKX2-2 SOX10 SOX8
Entrez ID		4821	10215
HPRD ID		05213	07334
Ensembl ID		ENSG00000125820	ENSG00000205927
Uniprot IDs		O95096	Q13516
PDB IDs
Enriched GO Terms of Interacting Partners?
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