OLIG2 and NKX2-2

Number of citations of the paper that reports this interaction (PubMedID 14573534)
26

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		OLIG2	NKX2-2
Description		oligodendrocyte transcription factor 2	NK2 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Identical Protein Binding Protein Dimerization Activity HMG Box Domain Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Thalamus Development Myelination Negative Regulation Of Neuron Differentiation Neuron Fate Commitment Positive Regulation Of Oligodendrocyte Differentiation	Type B Pancreatic Cell Development Pancreatic A Cell Fate Commitment Type B Pancreatic Cell Fate Commitment Pancreatic PP Cell Fate Commitment Smoothened Signaling Pathway Brain Development Response To Glucose Oligodendrocyte Development Spinal Cord Motor Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Optic Nerve Development Cell Differentiation Endocrine Pancreas Development Response To Progesterone Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Neuron Fate Specification Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of DNA-binding Transcription Factor Activity Ventral Spinal Cord Interneuron Fate Determination
Pathways			Regulation of gene expression in beta cells Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Drugs
Diseases
GWAS		Bulimia nervosa ( 23568457) Gastroesophageal reflux disease ( 31527586) Tea consumption ( 31046077)	Autism spectrum disorder ( 30804558) Chronotype ( 30696823) Ewing sarcoma ( 30093639) Hyperglycemia in higher physical activity ( 30327367) Lupus nephritis in systemic lupus erythematosus ( 24925725)
Interacting Genes		5 interacting genes: CUL3 EP300 NKX2-2 SOX10 SOX8	1 interacting genes: OLIG2
Entrez ID		10215	4821
HPRD ID		07334	05213
Ensembl ID		ENSG00000205927	ENSG00000125820
Uniprot IDs		Q13516	O95096
PDB IDs
Enriched GO Terms of Interacting Partners?
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