ATP1B1 and HCRTR1

		ATP1B1	HCRTR1
Description		ATPase Na+/K+ transporting subunit beta 1	hypocretin receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Sodium:potassium-exchanging ATPase Complex Caveola Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane T-tubule Organelle Membrane Sperm Flagellum Sarcolemma Extracellular Exosome Extracellular Vesicle	Cell Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	ATPase Activator Activity Sodium:potassium-exchanging ATPase Activity Protein Binding ATP Binding Protein C-terminus Binding Drug Binding ATPase Activity Cation-transporting ATPase Activity Protein Kinase Binding MHC Class II Protein Complex Binding Potassium Ion Binding Sodium Ion Binding Protein Heterodimerization Activity ATPase Binding	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Response To Hypoxia Cellular Calcium Ion Homeostasis Cellular Sodium Ion Homeostasis Cell Adhesion Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Potassium Ion Homeostasis Positive Regulation Of ATPase Activity Ion Transmembrane Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Protein Transport Into Plasma Membrane Raft ATP Metabolic Process Protein Stabilization Leukocyte Migration Relaxation Of Cardiac Muscle Cardiac Muscle Contraction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Repolarization Membrane Repolarization During Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cation Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Sodium Ion Export Across Plasma Membrane Positive Regulation Of Calcium:sodium Antiporter Activity Positive Regulation Of Potassium Ion Import Regulation Of Cardiac Conduction Potassium Ion Import Across Plasma Membrane	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Basigin interactions Ion homeostasis Ion transport by P-type ATPases	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs			Suvorexant
Diseases
GWAS		Coronary artery disease ( 29212778) Electrocardiographic traits ( 25055868) Fuchs's corneal dystrophy ( 28358029) Mitochondrial DNA levels ( 25240745) QT interval ( 23166209 29213071 24952745 19305409) Rosacea symptom severity ( 29771307)	Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566)
Interacting Genes		26 interacting genes: BACE1 BARD1 BRCA1 CD84 CREG1 CRIP2 DDAH2 EGFR EZH2 FXYD1 FXYD7 GCH1 HCRTR1 KMT2B LRIF1 NDRG2 PAXIP1 PRRX1 PSME1 SERPINC1 THOC1 TM4SF1 TRIM14 TRMT2A TSC22D2 USP4	6 interacting genes: ARRB1 ARRB2 ATP1B1 CNR1 HCRT PABPC4
Entrez ID		481	3061
HPRD ID		01663	03863
Ensembl ID		ENSG00000143153	ENSG00000121764
Uniprot IDs		A3KLL5 P05026	A6NMV7 O43613
PDB IDs			4ZJ8 4ZJC
Enriched GO Terms of Interacting Partners?
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