NEDD9 and MICAL1

Number of citations of the paper that reports this interaction (PubMedID 11827972)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		NEDD9	MICAL1
Description		neural precursor cell expressed, developmentally down-regulated 9	microtubule associated monooxygenase, calponin and LIM domain containing 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Actin Cytoskeleton Midbody Intercellular Bridge Hippocampal Mossy Fiber Expansion
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Actin Binding Protein Binding NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Rab GTPase Binding Protein Kinase Binding Metal Ion Binding Actin Filament Binding FAD Binding
	Biological Process	Cytoskeleton Organization Cell Cycle Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Regulation Of Growth Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Activation Of GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Signal Transduction Blood Coagulation Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Bundle Assembly Oxidation-reduction Process Regulation Of Regulated Secretory Pathway
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)	Depression in smokers ( 30219690) Height ( 28552196)
Interacting Genes		45 interacting genes: ABL1 APP AURKA BANP BCAR1 BCAR3 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 ELSPBP1 FYN FZR1 ID2 ITCH LCK LYN MICAL1 NAB2 NCK1 NFKBIA NOTCH3 PIK3CA PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 TCF3 TFCP2 TRIM27 TRIP6 ZNF318 ZYX	16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM
Entrez ID		4739	64780
HPRD ID		11888	06183
Ensembl ID		ENSG00000111859	ENSG00000135596
Uniprot IDs		A0A024QZV9 A0A087WUD2 Q14511	Q8TDZ2
PDB IDs		2L81 5X3S	1WYL 2CO8 2DK9 5LE0 5LPN
Enriched GO Terms of Interacting Partners?
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