MICAL1 and PIK3R3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		MICAL1	PIK3R3
Description		microtubule associated monooxygenase, calponin and LIM domain containing 1	phosphoinositide-3-kinase regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Actin Cytoskeleton Midbody Intercellular Bridge Hippocampal Mossy Fiber Expansion	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Actin Binding Protein Binding NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Rab GTPase Binding Protein Kinase Binding Metal Ion Binding Actin Filament Binding FAD Binding	Phosphotyrosine Residue Binding Protein Binding 1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Signal Transduction Blood Coagulation Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Bundle Assembly Oxidation-reduction Process Regulation Of Regulated Secretory Pathway	Positive Regulation Of Protein Phosphorylation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Phosphatidylinositol-3-phosphate Biosynthetic Process Protein Kinase B Signaling Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation
Pathways		Factors involved in megakaryocyte development and platelet production	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL
Drugs			Isoprenaline SF1126
Diseases
GWAS		Depression in smokers ( 30219690) Height ( 28552196)	Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Breast cancer ( 29059683) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Sodium levels ( 29403010) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM	81 interacting genes: ABCB6 ABL2 AMBP ANKS1A AUNIP AXL BRK1 BTK CAMK1 CCDC14 CCDC33 CEP126 CEP19 CLNK CRBN CRK DARS1 DCAF8 DRAP1 DSN1 E2F6 EGFR ERBB2 ERBB3 ESR1 FBN3 FER FGB FOXO1 FSD2 FYN GC HROB HSH2D IGF1R INSR IQUB IRS1 IRS2 KARS1 KHDRBS1 KLC2 KLF15 KMT2B L3MBTL3 LNX2 LUC7L2 MBIP MECOM MICAL1 MTF2 NCK1 ORM1 PACRGL PCDHB5 PDGFRB PELO PIK3CA PLB1 PPARA PSME1 QARS1 RB1 RING1 SERF1A SOCS6 SRC STAT3 TEC TERF2 TNNC2 TRIM54 TRMT2A TSPAN2 USP2 VBP1 VCP WRNIP1 ZMAT1 ZNF281 ZNF451
Entrez ID		64780	8503
HPRD ID		06183	05831
Ensembl ID		ENSG00000135596	ENSG00000117461
Uniprot IDs		Q8TDZ2	B4DXM8 Q68CY7 Q7Z3W2 Q8N381 Q92569
PDB IDs		1WYL 2CO8 2DK9 5LE0 5LPN
Enriched GO Terms of Interacting Partners?
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