RERE and EFEMP2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RERE	EFEMP2
Description		arginine-glutamic acid dipeptide repeats	EGF containing fibulin extracellular matrix protein 2
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cerebellar Purkinje Cell Layer Maturation Cerebellar Granule Cell Precursor Proliferation Radial Glia Guided Migration Of Purkinje Cell Branching Morphogenesis Of A Nerve Dendrite Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription	Elastic Fiber Assembly
Pathways			Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Diastolic blood pressure ( 27841878) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Feeling miserable ( 29500382) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 30598549 28869591) Hippocampal volume in normal cognition ( 29274321) Loneliness ( 31518406) Lymphocyte counts ( 27863252) Major depressive disorder ( 27479909) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Optic cup area ( 25631615 28073927) Schizophrenia ( 28991256 29483656 30285260) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Tonsillectomy ( 27182965 28928442) Total body bone mineral density ( 29304378) Upper eyelid morphology ( 29921221) Vertical cup-disc ratio ( 20548946 25241763) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitiligo ( 20410501 27723757) White blood cell count ( 27863252)	Acne (severe) ( 24927181) Birth weight ( 31043758)
Interacting Genes		20 interacting genes: ALG13 ATN1 CBFA2T2 ECM1 EFEMP1 EFEMP2 EHMT2 H3C14 KAT6A KRTAP4-12 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 TRIM22 TRIP6 ZMYND8	52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		473	30008
HPRD ID		05566	05221
Ensembl ID		ENSG00000142599	ENSG00000172638
Uniprot IDs		Q9P2R6	A0A024R5G1 O95967 Q9H3D5
PDB IDs		2YQK	2KL7
Enriched GO Terms of Interacting Partners?
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