NCL and CD3EAP

Number of citations of the paper that reports this interaction (PubMedID 23145133)
27

Data Source:
BioGRID (pull down)

		NCL	CD3EAP
Description		nucleolin	CD3e molecule associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex	RNA Polymerase I Transcription Factor Complex Fibrillar Center Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Mitochondrion Cytosol
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding	RNA Binding
	Biological Process	Angiogenesis Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway RRNA Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Height ( 31562340) Noise-induced hearing loss ( 26121033)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		53 interacting genes: ADAP1 ADAP2 CD3E CD3EAP CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 S100A11 SREK1 SRPK2 SSB STAU1 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZNF689	8 interacting genes: CD3E NCL NFKBIB POLR1C POLR1D POLR1E TAF1A UBTF
Entrez ID		4691	10849
HPRD ID		01245	00125
Ensembl ID		ENSG00000115053	ENSG00000117877
Uniprot IDs		B3KM80 P19338	O15446
PDB IDs		2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?
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