CD3EAP and POLR1C

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, far western blotting)

		CD3EAP	POLR1C
Description		CD3e molecule associated protein	RNA polymerase I and III subunit C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	RNA Polymerase I Transcription Factor Complex Fibrillar Center Nucleoplasm Chromosome Nucleolus RNA Polymerase I Complex Mitochondrion Cytosol	Nucleoplasm RNA Polymerase III Complex RNA Polymerase I Complex Cytosol
	Molecular Function	RNA Binding	RNA Polymerase I Activity RNA Polymerase III Activity DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway RRNA Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic	Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Gene Expression, Epigenetic
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: CD3E NCL NFKBIB POLR1C POLR1D POLR1E TAF1A UBTF	35 interacting genes: ATRIP BIRC7 CBY2 CCDC33 CD3EAP CLU CORO1A CORO1B IHO1 IKZF3 KCTD1 KRT19 LNX2 LZTS2 MBIP MKRN3 MYD88 MYO5B NFKBIB NME1 POLR1D POLR1E PPP2R3C RIMBP3 SAXO1 SMN2 TASOR2 TCF4 TFIP11 TNFAIP1 TRIM27 TRIOBP TSC22D4 VIM WRN
Entrez ID		10849	9533
HPRD ID		00125	09661
Ensembl ID		ENSG00000117877	ENSG00000171453
Uniprot IDs		O15446	O15160
PDB IDs
Enriched GO Terms of Interacting Partners?
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