MYL2 and USP6

Number of citations of the paper that reports this interaction (PubMedID 16555005)
2

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		MYL2	USP6
Description		myosin light chain 2	ubiquitin specific peptidase 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Actin Cytoskeleton Myosin Complex Myofibril Sarcomere A Band Cardiac Myofibril	Cytoplasm Lysosome Plasma Membrane Recycling Endosome
	Molecular Function	Actin Monomer Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Myosin Heavy Chain Binding	Nucleic Acid Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity GTPase Activator Activity Protein Binding Calmodulin Binding Rab GTPase Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Striated Muscle Contraction Heart Development Post-embryonic Development Muscle Filament Sliding Negative Regulation Of Cell Growth Muscle Cell Fate Specification Muscle Fiber Development Cardiac Myofibril Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Positive Regulation Of The Force Of Heart Contraction	Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Transport Protein Deubiquitination Regulation Of Vesicle-mediated Transport Activation Of GTPase Activity
Pathways		Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM)
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (max-drinks) ( 29460428) Body mass index ( 24861553) Coffee consumption ( 29367735) Coronary heart disease ( 23364394) Drinking behavior ( 23364009) Gamma glutamyl transpeptidase ( 21909109) Glycemic traits ( 23575436) Gout ( 25646370) HDL cholesterol ( 21909109) HDL cholesterol levels ( 28334899) High density lipoprotein cholesterol levels ( 30718733) Metabolic syndrome ( 25705158) Metabolic syndrome (multivariate analysis) ( 29632305) Neutrophil count ( 29403010) Urate levels ( 31578528) White blood cell count ( 29403010)	PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575)
Interacting Genes		11 interacting genes: CDC42BPA GJB5 LRSAM1 MYOC NHP2 PAK2 PKM PPP1R12C TRIM63 USP6 ZNF529	14 interacting genes: ANKRD44 APP ATXN7L3 CALM2 CDC42 EXOSC8 JAK1 JUN MDFI MYL2 RAB33B RAC1 TFIP11 UBC
Entrez ID		4633	9098
HPRD ID		01181	06827
Ensembl ID		ENSG00000111245	ENSG00000129204
Uniprot IDs		P10916 Q6IB42	P35125
PDB IDs		5TBY
Enriched GO Terms of Interacting Partners?
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