MYH2 and OBSCN

Number of citations of the paper that reports this interaction (PubMedID 15013951)
31

Data Source:
HPRD (in vivo)

		MYH2	OBSCN
Description		myosin heavy chain 2	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Myosin Complex Cell-cell Junction Myofibril Sarcomere Myosin Filament Protein-containing Complex	Cytosol Plasma Membrane Nuclear Body Myofibril Z Disc M Band Sarcolemma
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Muscle Contraction Muscle Filament Sliding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Protein Localization To M-band Positive Regulation Of Apoptotic Process Sarcomere Organization Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033)
Interacting Genes		6 interacting genes: AMPD1 DGKD OBSCN PRKCE PTK2B S100A4	7 interacting genes: ANK1 ANK2 BRCA1 CALM1 MTDH MYH2 TTN
Entrez ID		4620	84033
HPRD ID		01173	10551
Ensembl ID		ENSG00000125414	ENSG00000154358
Uniprot IDs		Q9UKX2	A6NGQ3 Q5VST9
PDB IDs			1V1C 2CR6 2DKU 2DM7 2E7B 2EDF 2EDH 2EDL 2EDQ 2EDR 2EDT 2EDW 2ENY 2EO1 2GQH 2MWC 2N56 2YZ8 4C4K 4RSV 4UOW 5TZM 6MG9
Enriched GO Terms of Interacting Partners?
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