MUSK and DOK7

Number of citations of the paper that reports this interaction (PubMedID 16794080)
118

Data Source:
HPRD (in vivo)

		MUSK	DOK7
Description		muscle associated receptor tyrosine kinase	docking protein 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Junction Neuromuscular Junction Receptor Complex Postsynaptic Membrane	Nucleoplasm Mitochondrion Plasma Membrane Cell Junction Synapse
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Lipid Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of ERK1 And ERK2 Cascade Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation	Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways		ECM proteoglycans
Drugs
Diseases		Congenital myasthenic syndrome	Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS		Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)	Calcium levels ( 29403010) Fibrinogen levels ( 28107422) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
Interacting Genes		7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1	7 interacting genes: APPL1 BCAR1 CRK EFHC1 MPZL1 MUSK YPEL3
Entrez ID		4593	285489
HPRD ID		03190	08744
Ensembl ID		ENSG00000030304	ENSG00000175920
Uniprot IDs		A0A087WSY1 O15146	A0A1W2PRA3 Q18PE1 Q8N1M3
PDB IDs
Enriched GO Terms of Interacting Partners?
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