DOK7 and MUSK

Number of citations of the paper that reports this interaction (PubMedID 16794080)
118

Data Source:
HPRD (in vivo)

		DOK7	MUSK
Description		docking protein 7	muscle associated receptor tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Plasma Membrane Cell Junction Synapse	Integral Component Of Plasma Membrane Cell Junction Neuromuscular Junction Receptor Complex Postsynaptic Membrane
	Molecular Function	Lipid Binding Protein Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Protein Tyrosine Kinase Activity	Positive Regulation Of Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Neuromuscular Junction Development Memory Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Positive Regulation Of Kinase Activity Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of ERK1 And ERK2 Cascade Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Protein Geranylgeranylation
Pathways			ECM proteoglycans
Drugs
Diseases		Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1	Congenital myasthenic syndrome
GWAS		Calcium levels ( 29403010) Fibrinogen levels ( 28107422) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)	Body mass index ( 28552196) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Pulmonary function decline ( 22424883) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860)
Interacting Genes		7 interacting genes: APPL1 BCAR1 CRK EFHC1 MPZL1 MUSK YPEL3	7 interacting genes: COLQ DOK7 ERBIN ILKAP RAPSN STYX SYNE1
Entrez ID		285489	4593
HPRD ID		08744	03190
Ensembl ID		ENSG00000175920	ENSG00000030304
Uniprot IDs		A0A1W2PRA3 Q18PE1 Q8N1M3	A0A087WSY1 O15146
PDB IDs
Enriched GO Terms of Interacting Partners?
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