MSX1 and RGS7

Number of citations of the paper that reports this interaction (PubMedID 10862767)
28

Data Source:
HPRD (in vitro, in vivo)

		MSX1	RGS7
Description		msh homeobox 1	regulator of G protein signaling 7
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding Enhancer Binding	GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Muscle Organ Development Negative Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Positive Regulation Of BMP Signaling Pathway Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Stem Cell Differentiation Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Roof Of Mouth Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development BMP Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Mesenchymal Cell Apoptotic Process	Protein Folding G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity
Pathways			G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Tooth agenesis; Hypodontia Tooth and nail syndrome; Witkop syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Breast cancer and/or colorectal cancer ( 29698419) Congenital heart disease ( 23708191) Electrocardiographic conduction measures ( 19389651) Nonsyndromic cleft lip with cleft palate ( 28232668)	Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Ischemic stroke (cardioembolic) ( 29531354) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)
Interacting Genes		24 interacting genes: CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TLE5 TP53	16 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ
Entrez ID		4487	6000
HPRD ID		00866	03948
Ensembl ID		ENSG00000163132	ENSG00000182901
Uniprot IDs		P28360	B7Z223 B7Z257 P49802
PDB IDs			2A72 2D9J
Enriched GO Terms of Interacting Partners?
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