MMP14 and KASH5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MMP14	KASH5
Description		matrix metallopeptidase 14	KASH domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Golgi Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Extracellular Matrix Cytoplasmic Vesicle Melanosome Macropinosome Intermediate Filament Cytoskeleton	Chromosome, Telomeric Region Lateral Element Cell Nuclear Outer Membrane Integral Component Of Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Meiotic Spindle Pole
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding Metalloaminopeptidase Activity	Protein Binding Identical Protein Binding Dynein Complex Binding
	Biological Process	Skeletal System Development Angiogenesis Ovarian Follicle Development Response To Hypoxia Endothelial Cell Proliferation Endochondral Ossification Proteolysis Response To Oxidative Stress Male Gonad Development Response To Mechanical Stimulus Response To Hormone Positive Regulation Of Myotube Differentiation Positive Regulation Of Protein Processing Response To Organic Cyclic Compound Protein Processing Extracellular Matrix Disassembly Extracellular Matrix Organization Positive Regulation Of Cell Growth Lung Development Positive Regulation Of Cell Migration Collagen Catabolic Process Zymogen Activation Endodermal Cell Differentiation Chondrocyte Proliferation Astrocyte Cell Migration Response To Estrogen Positive Regulation Of B Cell Differentiation Negative Regulation Of Notch Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Branching Morphogenesis Of An Epithelial Tube Tissue Remodeling Cell Motility Negative Regulation Of Focal Adhesion Assembly Head Development Craniofacial Suture Morphogenesis Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macrophage Migration Response To Odorant	Double-strand Break Repair Via Homologous Recombination Actin Filament Organization Synapsis Spermatogenesis Telomere Localization Oogenesis Spindle Assembly Spindle Localization Microtubule Cytoskeleton Organization Involved In Homologous Chromosome Segregation Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases
Drugs		Marimastat
Diseases
GWAS		Diastolic blood pressure ( 30224653) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 29892016) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		26 interacting genes: ACAN ADI1 BCAR1 C1QBP CAV1 CCL7 CLDN1 F12 FURIN ITGAV KASH5 KISS1 LRP1 LUM MMP13 MMP2 MMP3 PLLP RRAD SDC1 SPOCK1 SPOCK3 TIMP1 TIMP2 TIMP3 TIMP4	76 interacting genes: ABHD1 ADIPOQ ATF7 BAG5 BCL2L2 BET1 CCDC87 CDC73 CDKL3 CIB3 CLDN8 CRABP2 CXCL16 CXCL9 CYBC1 EMD FAM161A FAM90A1 FATE1 FIS1 FRA10AC1 FTCD GABARAPL2 GALNT2 GOSR2 GPATCH4 GPR25 HMOX1 ITM2B JAGN1 KDM1A LARP1 LAT LENG1 LHFPL5 LMNA MALL MARCHF2 MFSD5 MMP14 MS4A1 MTX2 NRIP3 NSG1 NTAQ1 OLFM4 PDGFRA PLP2 PPP1R18 RIPPLY2 RNF146 RSRC2 RTP2 SENP2 SERP2 SGTA SHMT2 SLC30A2 SLC41A2 SLN SMCO4 STBD1 STX5 TCF25 TMEM11 TMEM14C TMEM199 TMEM41A TMPRSS4 TRAF3IP3 TSHZ3 UPK1B UPK2 VAMP1 VAMP4 ZNF250
Entrez ID		4323	147872
HPRD ID		02856	08134
Ensembl ID		ENSG00000157227	ENSG00000161609
Uniprot IDs		P50281	Q8N6L0
PDB IDs		1BQQ 1BUV 2MQS 3C7X 3MA2 3X23 4P3C 4P3D 4QXU 5H0U 6CLZ 6CM1
Enriched GO Terms of Interacting Partners?
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