ASGR1 and HSP90B1

Number of citations of the paper that reports this interaction (PubMedID 12167617)
7

Data Source:
HPRD (in vivo)

		ASGR1	HSP90B1
Description		asialoglycoprotein receptor 1	heat shock protein 90 beta family member 1
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Cell Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Metal Ion Binding	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding
	Biological Process	Receptor-mediated Endocytosis Viral Process Protein N-linked Glycosylation Via Asparagine Cellular Response To Extracellular Stimulus	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP
Pathways		Asparagine N-linked glycosylation	Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs			Rifabutin 2-Chlorodideoxyadenosine Geldanamycin 1-Methoxy-2-(2-Methoxyethoxy)Ethane N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 31666285 29403010)	Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)
Interacting Genes		14 interacting genes: APP ASGR2 CERS2 CLEC4G DHFR HIVEP1 HSP90AA1 HSP90B1 LAMTOR5 LMNA NLK RBBP6 TG VKORC1	28 interacting genes: APOB ASGR1 BIRC2 CACYBP CCT2 CSNK2A1 CSNK2A2 EGFR ERBB2 ESR1 FANCC HSPA9 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTPN11 SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11
Entrez ID		432	7184
HPRD ID		00151	01860
Ensembl ID		ENSG00000141505	ENSG00000166598
Uniprot IDs		P07306 Q6FGQ5	P14625 V9HWP2
PDB IDs		1DV8 5JPV 5JQ1	4NH9
Enriched GO Terms of Interacting Partners?
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