MKLN1 and RANBP9

Number of citations of the paper that reports this interaction (PubMedID 27173435)
49

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		MKLN1	RANBP9
Description		muskelin 1	RAN binding protein 9
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Ruffle Nucleoplasm Cytoplasm Cytosol Cell Cortex Cell Junction Postsynapse	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane
	Molecular Function	Protein Homodimerization Activity	Protein Binding Ran GTPase Binding Enzyme Binding
	Biological Process	Regulation Of Receptor Internalization Cell-matrix Adhesion Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Reorganization	MAPK Cascade Microtubule Nucleation Axon Guidance Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade
Pathways			L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
Drugs
Diseases
GWAS		Asthma (childhood onset) ( 23829686) Bipolar disorder ( 31043756) Bipolar disorder (early onset) ( 27769005) Heel bone mineral density ( 30598549) Hyperglycemia in higher physical activity ( 30327367) Hypertension ( 28273873) Lung cancer in never smokers ( 28604730) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Pancreatic cancer ( 25086665) PR interval ( 30046033) Resting heart rate ( 27798624) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Systolic blood pressure ( 28135244) Vitamin D levels ( 25208829) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Breast cancer ( 29059683 23535729)
Interacting Genes		3 interacting genes: MAEA PTGER3 RANBP9	56 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 CACNA1G CALB1 CBS CCND1 CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LMNA MAPK6 MET MKLN1 MPHOSPH8 NCOA6 NCOR2 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 YPEL5
Entrez ID		4289	10048
HPRD ID		16129	04835
Ensembl ID		ENSG00000128585	ENSG00000010017
Uniprot IDs		B4DG30 Q9UL63	A0A024QZW3 Q96S59
PDB IDs			5JI7 5JI9 5JIU
Enriched GO Terms of Interacting Partners?
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