MFAP2 and BGN

Number of citations of the paper that reports this interaction (PubMedID 11723132)
52

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		MFAP2	BGN
Description		microfibril associated protein 2	biglycan
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding
	Biological Process	Extracellular Matrix Organization Embryonic Eye Morphogenesis Post-embryonic Eye Morphogenesis Positive Regulation Of Cold-induced Thermogenesis	Blood Vessel Remodeling Biological_process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Bone Development Articular Cartilage Development
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Chronic obstructive pulmonary disease ( 30804561) Height ( 20881960 25282103 25429064 23563607) Lung function (FEV1/FVC) ( 28166213 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500)
Interacting Genes		5 interacting genes: BGN COL4A3 ELN FBN1 FBN2	17 interacting genes: - APOB APP BMP4 CCN4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 TNF
Entrez ID		4237	633
HPRD ID		01137	02359
Ensembl ID		ENSG00000117122	ENSG00000182492
Uniprot IDs		A0A024RA94 P55001	B4DNL4 P21810
PDB IDs
Enriched GO Terms of Interacting Partners?
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