BGN and CCN4

Number of citations of the paper that reports this interaction (PubMedID 11598131)
39

Data Source:
HPRD (in vitro)

		BGN	CCN4
Description		biglycan	cellular communication network factor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Cytosol Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding	Integrin Binding Protein Binding Insulin-like Growth Factor Binding Heparin Binding
	Biological Process	Blood Vessel Remodeling Biological_process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Bone Development Articular Cartilage Development	Osteoblast Differentiation Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Smooth Muscle Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Osteoclast Differentiation Negative Regulation Of Chondrocyte Differentiation Glucose Homeostasis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cytokine Secretion Positive Regulation Of Inflammatory Response Bone Development Negative Regulation Of Cell Death Positive Regulation Of Wound Healing
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: - APOB APP BMP4 CCN4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 TNF	2 interacting genes: BGN DCN
Entrez ID		633	8840
HPRD ID		02359	16019
Ensembl ID		ENSG00000182492	ENSG00000104415
Uniprot IDs		B4DNL4 P21810	O95388
PDB IDs
Enriched GO Terms of Interacting Partners?
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