MEF2A and HAND1

Number of citations of the paper that reports this interaction (PubMedID 16043483)
18

Data Source:
BioGRID (pull down)

		MEF2A	HAND1
Description		myocyte enhancer factor 2A	heart and neural crest derivatives expressed 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Activating Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding SMAD Binding Protein Heterodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Transcription Factor Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding
	Biological Process	Mitochondrial Genome Maintenance Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Transcription, DNA-templated Apoptotic Process Multicellular Organism Development Heart Development Muscle Organ Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Mitochondrion Distribution Dendrite Morphogenesis Positive Regulation Of Muscle Cell Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Conduction ERK5 Cascade Cellular Response To Calcium Ion	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Mesoderm Formation Blastocyst Development Trophectodermal Cell Differentiation Heart Looping Embryonic Heart Tube Formation Cardiac Left Ventricle Formation Cardiac Right Ventricle Formation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Developmental Process Embryonic Heart Tube Development Odontogenesis Of Dentin-containing Tooth Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Septum Morphogenesis Mesenchyme Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		ERK/MAPK targets Myogenesis
Drugs
Diseases
GWAS		Cervical cancer ( 28806749) Dental caries (decayed and filled deciduous teeth) ( 31533690) Gestational age at birth (maternal effect) ( 28598419) Systolic blood pressure ( 30224653 30578418)	Chin dimples ( 27182965) Global electrical heterogeneity phenotypes ( 29622589) Monobrow ( 27182965) QRS complex (Cornell) ( 27659466) QRS duration ( 30679814 27577874 31251759 25035420)
Interacting Genes		28 interacting genes: ACTN4 ASCL1 CASP3 CASP7 CDK5 DDB1 DNMT3L EP300 ERBIN HAND1 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MEOX1 MYOD1 MYOG NDUFB9 PHB2 SMAD2 SMAD4 SUMO1 TEAD1 THRA VGLL4	15 interacting genes: ACHE DNMT3L FHL2 G3BP1 HAND2 HEY2 HEYL MEF2A MYOD1 PPP2R5D PRKACA PRKCA SRA1 TCF12 TCF3
Entrez ID		4205	9421
HPRD ID		02807	03871
Ensembl ID		ENSG00000068305	ENSG00000113196
Uniprot IDs		A0A0S2Z417 A0A0S2Z453 A0A0S2Z454 A0A0S2Z4C8 A0A0S2Z4N0 A8K720 Q02078	O96004
PDB IDs		1C7U 1EGW 1LEW 3KOV 3MU6 3P57 6BYY 6BZ1
Enriched GO Terms of Interacting Partners?
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